Biography

Billy De Los Santos, MD, is an internal medicine doctor board-certified by the American Board of Internal Medicine. 

Dr. De Los Santos was born and raised in Brooklyn, NY, where he initially developed a passion for providing quality health care to underserved populations. In his practice, he cares for patients like he would his own family members, ensuring they receive quality treatment.

Dr. De Los Santos' favorite aspect of being a doctor is establishing trust and strong bonds with his patients. He takes time to listen to them, ensuring they feel valued, understood and an equal partner in their health. Diabetes, geriatrics, heart disease, cholesterol, and thyroid disorders are some of Dr. De Los Santos's many clinical interests.

Dr. De Los Santos currently lives in Plano, Texas, where he enjoys spending quality time with his wife and two sons.

Clinical interests

Diabetes
Geriatrics
Heart disease
High blood pressure
High cholesterol
Internal medicine
Preventive care
Thyroid disease

Locations

Office Hours
Sunday Closed
Monday 7 a.m. to 5 p.m.
Tuesday 7 a.m. to 5 p.m.
Wednesday 7 a.m. to 5 p.m.
Thursday 7 a.m. to 5 p.m.
Friday 7 a.m. to 5 p.m.
Saturday Closed

Education and credentials

Residency
Jacobi Medical Center
Medical school
Ross University School of Medicine
Intern/residency
Queens Hospital Center
Intern/residency
Saint Vincents Hospital & Med Center

Accepted insurances

We accept many major health insurance plans. Insurance plans accepted vary by doctor and can change. Please call your clinic directly to confirm what insurances are accepted.
Clinician numbers for agent use only.
BCBS (See payor website)
Humana (See payor website)
Superior Health (See payor website)
UnitedHealthcare (See payor website)
Wellcare (1386885614)

Patient Reviews

Learn about our survey
5
138
4
2
3
0
2
0
1
0

140 Results

  • March 31, 2026

    Verfied Review

    5 out of 5 patient rating

    He goes over everything, answers all you questions and make sure you understand everything that is going on

  • March 02, 2026

    Verfied Review

    5 out of 5 patient rating

    He is very patient and polite. He listens carefully and responds to all questions. I usually go in with high blood pressure because I always am anxious about going to any doctor. I leave with my pressure being normal.

  • March 09, 2026

    Verfied Review

    5 out of 5 patient rating

    He listened and I think he covered my medical needs.

  • January 27, 2026

    Verfied Review

    5 out of 5 patient rating

    Caring, informed and professional

  • January 18, 2026

    Verfied Review

    5 out of 5 patient rating

    Dr D is the only Dr. for me, with 12 years of his experience, no one else could fill his shoes. He was so determined to get my A1C under control, one could see the thought process working to meet that goal. He truly has a calling, a wonderful intellectual physician.

  • February 27, 2026

    Verfied Review

    5 out of 5 patient rating

    Very professional and always takes time to discuss my medical issues in detail so I understand the importance of the next steps.

  • February 16, 2026

    Verfied Review

    5 out of 5 patient rating

    He seemed interested in making sure I understood what he was covering, asked me appropriate questions, and answered my questions.

  • January 23, 2026

    Verfied Review

    5 out of 5 patient rating

    Because Billy de Los Santos has been my physician for a number of years. He is very thorough and professional. He asks questions and makes sure he is really concerned about my health and well being.. I would recommend him to anyone looking for a great doctor.

  • February 02, 2026

    Verfied Review

    5 out of 5 patient rating

    Very knowledgeable, polite, pleasant conversation, trustworthy

  • February 25, 2026

    Verfied Review

    5 out of 5 patient rating

    As I stated earlier, Dr de los Santos is great! Patient in taking all the time needed for my appointments, explains everything in a manner I can understand, and listens to my questions.

  • January 25, 2026

    Verfied Review

    5 out of 5 patient rating

    Very professional and always willing to answer questions you might have about anything going on with the patient.

  • January 17, 2026

    Verfied Review

    5 out of 5 patient rating

    All was great!

  • December 08, 2025

    Verfied Review

    5 out of 5 patient rating

    Great Dr listens and answers questions takes interest in you.

  • December 09, 2025

    Verfied Review

    5 out of 5 patient rating

    Great doctor let me know probably having swelling above my left knee unstand me a lot about my my health everyone work with him great people

  • December 11, 2025

    Verfied Review

    5 out of 5 patient rating

    Great Dr. Listens toyou

  • December 06, 2025

    Verfied Review

    5 out of 5 patient rating

    I've received good care with Dr. Santos and his staff.

  • November 25, 2025

    Verfied Review

    5 out of 5 patient rating

    The doctor is friendly and thorough. He explains clearly your symptoms and treatment plan. I would recommend him to others without reservation

  • November 07, 2025

    Verfied Review

    5 out of 5 patient rating

    Outstanding Doctor

  • November 03, 2025

    Verfied Review

    5 out of 5 patient rating

    Dr Santos is knowledgeable and takes the time to answer any questions I have. He refers me to other doctors if I request/need them.

  • November 21, 2025

    Verfied Review

    5 out of 5 patient rating

    He is a very caring, polite and respectful doctor. He is genuinely, and care about his patients. He explained everything to you so I can understand what’s going on. Me personal I love the treatment I received from him.💯

  • November 15, 2025

    Verfied Review

    5 out of 5 patient rating

    I have been with this Doctor for about 12 yrs now he is very passionate about his clients.

  • November 26, 2025

    Verfied Review

    5 out of 5 patient rating

    He is very attentive and easy to talk with. He works with me to isolate any issue.

  • October 04, 2025

    Verfied Review

    5 out of 5 patient rating

    Biggest key----He listens. He really cares and goes to extremes to find the best solutions. I have been seeing him now for a few years and have developed a trust that he treats me properly.

  • October 11, 2025

    Verfied Review

    5 out of 5 patient rating

    He is thorough and relates well to me.

  • October 28, 2025

    Verfied Review

    5 out of 5 patient rating

    He really cared for my well being and he has taken care of me for a long time.

  • October 10, 2025

    Verfied Review

    5 out of 5 patient rating

    IVE BEEN BILLY SANTOS PATIENT FOR A WHILE NOW , AND FILL HE LISTEN TO MY PROBLEMS AND SITUATIONS, AND GETS MY MEDS TO ME ON TIME, HES A GREAT 👍 👌 ✨️ PHYSICAN TO ME , TAKES CARE OF MY NEEDS TO STAYING WELL

  • September 04, 2025

    Verfied Review

    5 out of 5 patient rating

    He is through and asks a lot of questions about my health. He is very focused on his work. He also interacts very well with patients.

  • September 12, 2025

    Verfied Review

    5 out of 5 patient rating

    Great Doctor!

  • September 04, 2025

    Verfied Review

    5 out of 5 patient rating

    He's professional, very knowledgeable, friendly, caring and a very good and thorough physician. He truly cares about the overall well-being of his patients.

  • September 04, 2025

    Verfied Review

    5 out of 5 patient rating

    He help me to understand about every thing for my health

  • September 27, 2025

    Verfied Review

    5 out of 5 patient rating

    I have been going to Dr De Los Santos for 6 years now and he is the kindest nicest doctor - he helps me when I need to know anything concerning my prescriptions or my health which I really appreciate - he never rushes me out he goes over all tests I had to do before I came back to my 3 to 4 month checkup ie:; mammogram, bone density etc always glad to get those results and he explains what I need to do at every step to maintain my health - I would recommend him to anyone and I have - One thing Dr De Los Santos needs to know is while waiting to get blood work done the girl doing the blood work was more interested in talking to everyone and I was the only one waiting and she would not let me sit in the room of the test she made me sit in the black chairs I had not ever seen her before kind of off putting to say the least

  • August 01, 2025

    Verfied Review

    5 out of 5 patient rating

    He’s very professional, easy to talk to, explains everything in detail. Has been able to see us at the scheduled times.

  • August 22, 2025

    Verfied Review

    5 out of 5 patient rating

    Dr De Los Santos is personable and thorough. His treatment recommendations are spot on.

  • August 29, 2025

    Verfied Review

    5 out of 5 patient rating

    Doctor is professional, friendly, and listens.

  • August 29, 2025

    Verfied Review

    5 out of 5 patient rating

    Have had Dr DeLosSantos for several years and are very pleased with him.

  • August 30, 2025

    Verfied Review

    5 out of 5 patient rating

    He is very understanding and listens to your needs and what your needs are!

  • August 24, 2025

    Verfied Review

    5 out of 5 patient rating

    I am very comfortable with my doctor. I don't take to doctors very well. I don't even like going to the doctor. But with Dr. Santos I feel, I feel more relaxed and at ease with him.

  • August 28, 2025

    Verfied Review

    5 out of 5 patient rating

    Very friendly and caring doctor.

  • August 24, 2025

    Verfied Review

    5 out of 5 patient rating

    He's been my doctor for a long time. He helps me be involved in my own care.

  • August 12, 2025

    Verfied Review

    5 out of 5 patient rating

    Explained in previous typed box.

  • July 03, 2025

    Verfied Review

    5 out of 5 patient rating

    IVE BEEN WITH DOCTOR'S NOW FOR ABOUT 6 YEARS NOW AND PERFER MY PRIMARY DOCTOR'S ALWAYS TO HELP ME 😢 ON MY APPOINTMENTS DATES

  • July 03, 2025

    Verfied Review

    5 out of 5 patient rating

    He is a great doctor

  • July 26, 2025

    Verfied Review

    5 out of 5 patient rating

    he asks questions and listens offers advise and is friendly and does not rush me.

  • July 24, 2025

    Verfied Review

    5 out of 5 patient rating

    I like him

  • July 06, 2025

    Verfied Review

    5 out of 5 patient rating

    He takes the time to listen and explain when needed.

  • July 10, 2025

    Verfied Review

    5 out of 5 patient rating

    He's always very professional and caring about my health care.

  • July 08, 2025

    Verfied Review

    5 out of 5 patient rating

    Because Dr. Billy de Los Santos has always been professional and answers all my questions if I have any in a professional manner..

  • July 16, 2025

    Verfied Review

    5 out of 5 patient rating

    Very likely!

  • July 29, 2025

    Verfied Review

    5 out of 5 patient rating

    He is very thorough, concerned and professional.

  • July 22, 2025

    Verfied Review

    5 out of 5 patient rating

    He is the best of the best. Years of friendship as my doctor.

  • June 26, 2025

    Verfied Review

    5 out of 5 patient rating

    Very nice, easy to talk with, reviews the previous lab works and orders what is needed

  • May 21, 2025

    Verfied Review

    5 out of 5 patient rating

    A good doctor,that takes time to learn from illness and treatment.

  • May 05, 2025

    Verfied Review

    5 out of 5 patient rating

    Because my husband enjoys this doctor.

  • May 15, 2025

    Verfied Review

    5 out of 5 patient rating

    He is a wonderful Doctor

  • May 19, 2025

    Verfied Review

    5 out of 5 patient rating

    he is inform all it need to my visit

  • May 18, 2025

    Verfied Review

    5 out of 5 patient rating

    He is kind, caring, and informative. Great Doctor!

  • May 21, 2025

    Verfied Review

    5 out of 5 patient rating

    I personally find him approachable, knowledgeable, and courteous.

  • May 31, 2025

    Verfied Review

    5 out of 5 patient rating

    Because he cares.

  • May 24, 2025

    Verfied Review

    5 out of 5 patient rating

    Professional, capable, friendly, perso able

  • May 01, 2025

    Verfied Review

    5 out of 5 patient rating

    Have been patients(wife and I) with Dr De Los Santos for several years and have been very pleased with his service.

  • May 18, 2025

    Verfied Review

    5 out of 5 patient rating

    Excellent provider. Listens. Takes time with you.

  • April 09, 2025

    Verfied Review

    5 out of 5 patient rating

    Dr Santos cares about his patients well being.

  • April 04, 2025

    Verfied Review

    5 out of 5 patient rating

    He's always very professional and He cares about the well being of his patient's.

  • April 13, 2025

    Verfied Review

    5 out of 5 patient rating

    I have been seeing Dr Billy De Los Santos for a great amount of time. Very knowledgeable and respectful. He really gives me satisfaction when he is finished with the visit. I would recommend him to any one who is looking for a good respective doctor.

  • April 15, 2025

    Verfied Review

    5 out of 5 patient rating

    Dr. De Los Santos is understanding and relates well with me. He understands my concerns and/or lack of concern about my health.

  • April 30, 2025

    Verfied Review

    5 out of 5 patient rating

    He is very concerned about his patients health and will listen to you if you have questions regarding your health care. If you ask questions, he can generally answer them and explain his reasons as to why he agrees or disagrees.

  • April 03, 2025

    Verfied Review

    5 out of 5 patient rating

    He is very thorough and keeps me informed on all my health questions/issues.

  • April 30, 2025

    Verfied Review

    5 out of 5 patient rating

    He has always provided my family with what we need.

  • April 12, 2025

    Verfied Review

    5 out of 5 patient rating

    Dr De Los Santo was very informative and helpful withmeds and my condition and wel care.

  • April 07, 2025

    Verfied Review

    5 out of 5 patient rating

    Because this survey asked me to.

  • April 09, 2025

    Verfied Review

    5 out of 5 patient rating

    Dr. Billy is a very caring doctor.

  • April 04, 2025

    Verfied Review

    5 out of 5 patient rating

    Dr. De Los Santos is an excellent physician, but more importainly, he demonstrates the qualities that have become quite rare in the medical profession. He treats every patient with respect and dignity, takes the time to listen, and shows genuine concern when you need it most. I trust him with not only my health, but with the lives of the people that are dearest to me. On a scale of 1 to 10, Dr. De Los Santos is a solid 12!

  • April 08, 2025

    Verfied Review

    5 out of 5 patient rating

    I have followed him for 8 years. He is nice and knows his stuff.

  • April 13, 2025

    Verfied Review

    5 out of 5 patient rating

    Takes time to listen and plan treatment

  • April 04, 2025

    Verfied Review

    5 out of 5 patient rating

    10....Dr. Santos is an excellent physician and I really feel at ease talking to him. There is no rushing even though he has a busy schedule. He has been my PCP for over 10 years now and I feel that his services are helping me to stay healthy and happy through his guidance and advice as he review my tests results.

  • April 10, 2025

    Verfied Review

    5 out of 5 patient rating

    Understanding. Thorough. Friendly

  • April 03, 2025

    Verfied Review

    5 out of 5 patient rating

    Because he takes his time and consults with his patients meticulously.

  • March 30, 2025

    Verfied Review

    5 out of 5 patient rating

    He has been our PCP for a number of years and we have been very satisfied with him.

  • March 31, 2025

    Verfied Review

    5 out of 5 patient rating

    Dr. Santos is very caring, I feel very comfortable and more relaxed talking to him. He is a good listener and helps me understand the issues on what is going on.

  • March 31, 2025

    Verfied Review

    5 out of 5 patient rating

    Because he's a good provider. He listens and seems to give good recommendations

  • March 23, 2025

    Verfied Review

    5 out of 5 patient rating

    He's very knowledgeable about my conditions and medicine and explaining everything I need to no about self care

  • March 30, 2025

    Verfied Review

    5 out of 5 patient rating

    always receive good service

  • January 19, 2025

    Verfied Review

    5 out of 5 patient rating

    He is always friendly, professional and willing to talk with me about any concerns or questions I have about my health.

  • January 23, 2025

    Verfied Review

    5 out of 5 patient rating

    the Doctor is very good. he truly cares and sees you as long as needed. As a matter of fact if he ever leaves Sunnyvale as much as I like the staff I don't think that any other Doctor will do. Just a creature of habit I guess. I most likely would find out where he goes and if close enough I would stay with him

  • January 07, 2025

    Verfied Review

    5 out of 5 patient rating

    He is just a great doctor. Probably the best doctor I have ever had.

  • January 07, 2025

    Verfied Review

    5 out of 5 patient rating

    Been seeing him for years he is very thorough

  • February 01, 2025

    Verfied Review

    5 out of 5 patient rating

    He was very thorough with his questions

  • December 04, 2024

    Verfied Review

    5 out of 5 patient rating

    Good relationship with him, knows issues and just like and trust him

  • December 06, 2024

    Verfied Review

    5 out of 5 patient rating

    Para mi es un Dr estupendo

  • December 26, 2024

    Verfied Review

    5 out of 5 patient rating

    Caring doctor

  • December 26, 2024

    Verfied Review

    5 out of 5 patient rating

    Very caring and professional. Explained tings so I can understand them.

  • August 13, 2024

    Verfied Review

    5 out of 5 patient rating

    Very efficient, concerned, he really understands his patients

  • May 02, 2024

    Verfied Review

    5 out of 5 patient rating

    Great Dr and listen to your concerns and needs

  • September 28, 2024

    Verfied Review

    5 out of 5 patient rating

    He is respectful, complimentary of my good health, explains any recommendations thoroughly,

  • June 05, 2024

    Verfied Review

    5 out of 5 patient rating

    Extremely likely

  • March 11, 2024

    Verfied Review

    5 out of 5 patient rating

    He is very kind and always takes the time to go over results from previous visits and explains things in a way that I can undersand them -Thank you for all you do to keep me healthy

  • January 16, 2024

    Verfied Review

    5 out of 5 patient rating

    I think he is one of the nicest Doctors I have had in many years and I believe he knows his Profession.

  • March 06, 2024

    Verfied Review

    5 out of 5 patient rating

    I consider him an excellent Doctor and value his opinions and diagnosis.

  • November 09, 2024

    Verfied Review

    5 out of 5 patient rating

    He's a great Dr.talk with me about all my medicine and what's it for and any questions I have are addressed and answer my overall visits are to my satisfaction

  • January 08, 2024

    Verfied Review

    5 out of 5 patient rating

    He seems to care about the wellbeing of him patients

  • March 27, 2024

    Verfied Review

    5 out of 5 patient rating

    Always takes the time to explain, and is caring and very professional!

  • August 09, 2024

    Verfied Review

    5 out of 5 patient rating

    He is everything I could ever hope for in a physician,

  • April 26, 2024

    Verfied Review

    5 out of 5 patient rating

    He is a very good dr and cares about your health

  • October 24, 2024

    Verfied Review

    5 out of 5 patient rating

    I think he is very thorough, and knowledgeable. He is caring and personable.

  • February 14, 2024

    Verfied Review

    5 out of 5 patient rating

    He's great

  • May 20, 2024

    Verfied Review

    5 out of 5 patient rating

    Very professional

  • June 27, 2024

    Verfied Review

    5 out of 5 patient rating

    Never in a rush, answers questions, spends necessary time with me

  • August 28, 2024

    Verfied Review

    5 out of 5 patient rating

    He treats us with professionalism and gives excellent feedback to our questions.

  • April 08, 2024

    Verfied Review

    5 out of 5 patient rating

    caring doctor

  • February 21, 2024

    Verfied Review

    5 out of 5 patient rating

    He is very through and is easy to communicate with. Very competent Dr.

  • February 21, 2024

    Verfied Review

    5 out of 5 patient rating

    He is professional, knowledgeable and caring..

  • May 23, 2024

    Verfied Review

    5 out of 5 patient rating

    His knowledge of my particular medical problems is remarkable. He is very professional with his care.

  • October 17, 2024

    Verfied Review

    5 out of 5 patient rating

    He doesn't rush my visits, takes time to actually listen to what I have to say, answers any questions I have.

  • August 06, 2024

    Verfied Review

    5 out of 5 patient rating

    He takes his time with you to listen to any concerns you may have and does the job to make sure he adresses it then not on the next visit

  • August 06, 2024

    Verfied Review

    5 out of 5 patient rating

    Friendly, listens to patient, very detailed oriented . Has best interest at heart for patient

  • March 22, 2024

    Verfied Review

    5 out of 5 patient rating

    My husband has always had a very good experience with Dr. Billy A De Los Santos.

  • May 08, 2024

    Verfied Review

    5 out of 5 patient rating

    He has been my Doctor for years. He shows a great deal of concern for my well being, and also puts up with me being a little difficult at times. I owe my good health to him.

  • October 16, 2024

    Verfied Review

    5 out of 5 patient rating

    He is awesome at caring for his

  • May 01, 2024

    Verfied Review

    5 out of 5 patient rating

    You can’t find anyone like him. Very respectful knowledge never makes me feel like he is judging me he takes the time to listen to my concerns gives back feed back and reaches out to me in a timely manner I feel like he truly cares about my well being. Best Doctor in the whole world.

  • March 11, 2024

    Verfied Review

    5 out of 5 patient rating

    He's very thorough and makes sure I'm doing well

  • August 12, 2024

    Verfied Review

    5 out of 5 patient rating

    The doctor always answers my questions or concerns that I may have.

  • January 04, 2024

    Verfied Review

    4.5 out of 5 patient rating

    Satisfied with care but his MA seemed to not know English well.

  • November 26, 2024

    Verfied Review

    5 out of 5 patient rating

    Dr. Santos is always thorough, caring, patient and answers all of my questions. Plus, I don't feel rushed with the visit. I have referred several people to him.

  • July 09, 2024

    Verfied Review

    5 out of 5 patient rating

    The best

  • November 28, 2024

    Verfied Review

    5 out of 5 patient rating

    Listens very patiently. Pleasant always, very knowledgeable, good bedside manner, good sense of humor, discusses lab results & plan of care.

  • August 21, 2024

    Verfied Review

    5 out of 5 patient rating

    Great Dr

  • March 11, 2024

    Verfied Review

    5 out of 5 patient rating

    Because he listens to what I have to say and is thorough in his examination and evaluation

  • July 08, 2024

    Verfied Review

    5 out of 5 patient rating

    Dr De Los Santos is the Best I will continue to go to him he helps me with all of my needs and keeps me going on what to do next love going to his office although as we all do I get nervous But he always calms me down even though he does not realize it when he starts talking to me

  • July 11, 2024

    Verfied Review

    5 out of 5 patient rating

    He's very thorough and caring

  • October 23, 2024

    Verfied Review

    5 out of 5 patient rating

    I love the way my doctor cares about not just my physical wellbeing but my mental wellbeing also. He knows my family and history, always ask to make sure I'm ok. He is very caring and always courteous. Always willing to help get me to a specialist if needed. I'm very satisfied with him.

  • May 30, 2024

    Verfied Review

    5 out of 5 patient rating

    Very kind, caring,friendly professional and knowledgeable.

  • April 21, 2024

    Verfied Review

    5 out of 5 patient rating

    Porque es muy competente y muy respetuoso y muy amable

  • February 14, 2024

    Verfied Review

    5 out of 5 patient rating

    Dr Santos is knowledgeable and caring. He takes time to talk about my concerns, answers my questions, and gives me recommendations about things.

  • February 07, 2024

    Verfied Review

    5 out of 5 patient rating

    Professional , friendly, caring. Willing to listen.

  • July 02, 2024

    Verfied Review

    4.5 out of 5 patient rating

    I enjoy talking with about my healt concerns

  • August 21, 2024

    Verfied Review

    5 out of 5 patient rating

    He listens to my concerns. He helps.me understand.

  • November 21, 2024

    Verfied Review

    5 out of 5 patient rating

    Very through and interested in his patients

  • January 31, 2024

    Verfied Review

    5 out of 5 patient rating

    Hasta ahora es un Dr que se preoucupa por mi cuidado medico.

  • May 06, 2024

    Verfied Review

    5 out of 5 patient rating

    He is a good dr,

  • May 21, 2024

    Verfied Review

    5 out of 5 patient rating

    HE'S MY SECOND DOCTOR SINCE IVE LIVED IN [omitted]. .. I CAN TALK AND EXPLAIN MY THOUGHTS AND NEEDS AND HE FOES LISTEN' ' AND I ALSO HAVE TO TO IN THE CARE MY BODY NEEDS SINCE IVE HAD HIGH BLOOD PRESSURE AT AND EARLY AGE AND THE HEALTH OF MY BODY NOW ' ' CONDITION